It is probably the biggest game across the history of the Premier League era, with Manchester United going up against their old foes, Arsenal.
While they may be two of the most successful sides in Premier League history, it has been a troubled few years for Arsenal and Manchester United.
Both have seen their long-serving managers depart, although early signs are showing that Arsenal have had a better succession plan than Manchester United, who seem to be slumping from one crisis to another with increasing regularity.
However, when the teams meet this week, it will still be a mouth-watering occasion, and we have put together a combined XI based on current form.
Take a look at our short video, and leave your comments in the box below with your thoughts.