Sassuolo
Lazio
>Sassuolo vs Lazio Prediction & Betting Tips – 27/10/2026
Sassuolo welcome Lazio to the MAPEI Stadium on Tuesday 27 October for a Serie A fixture that could further define the top-six narrative this season. Lazio sit second in the table and carry genuine title aspirations, while Sassuolo, languishing in thirteenth, need points to pull clear of the lower reaches. The visitors boast a flawless away record so far, making this a stern examination of the hosts' resolve. With Fedde Leysen ruled out through a serious knee injury, Sassuolo's defensive options look thin against one of the division's most potent attacking sides.
Match Analysis
Lazio arrive at the MAPEI Stadium as clear favourites at 2.40, backed by an unbeaten Serie A run of five wins and one draw from six matches, a perfect three-from-three away record, and a commanding eight-point gap over Sassuolo.
- 5W-1D-0L in Serie A this season, the best unbeaten run among visiting sides today.
- 3W-0D-0L away from home, with Lazio conceding just 0.67 goals per game across all league fixtures.
- 14 wins in 24 H2H meetings, including a 2-1 Serie A victory over Sassuolo as recently as March 2026.
- Cataldi's confirmed return adds midfield depth despite absences, while Sassuolo lose Koné, Boloca, and Candé in central areas.
Sassuolo face a steep climb at 2.80, sitting on just eight points from nine games with a recent run of LDLWD. Four key absentees in midfield and defence strip Domenico Berardi's side of crucial structural cover against a sharp Lazio attack.
- Sassuolo concede 1.67 goals per game, the worst defensive average in this fixture context.
- 2W-2D-3L in Serie A so far, with home form offering little protection against top-half opponents.
- Koné, Boloca, Candé, and Leysen all absent, leaving four first-team players unavailable in key defensive and midfield roles.
Key point: With Lazio's defence conceding under one goal per game and Sassuolo's attack misfiring, the double chance pairing with 2.20 offers a compact low-scoring alternative angle.
Form & Statistics: Sassuolo vs Lazio
Sassuolo
Recent form
Season statistics (5)
Lazio
Recent form
Season statistics (5)
Sassuolo vs Lazio: Head-to-Head
Average statistics (recent meetings)
Lineups: Sassuolo vs Lazio
Sassuolo
Starters
- 1 Arijanet Murić
- 2 Van Der Brempt
- 3 Duje Ćaleta-Car
- 4 Cas Odenthal
- 5 Josh Doig
- 6 Vasilije Adžić
- 7 Nemanja Matić
- 8 Darryl Bakola
- 9 Domenico Berardi
- 10 Sebastiano Esposito
- 11 Armand Laurienté
Bench
- Andrea Consigli
- Gian Marco Ferrari
- Jeremy Toljan
- Matheus Henrique
- Kristian Thorstvedt
- Nedim Bajrami
- Samu Castillejo
- Gregoire Defrel
- Kieron Bowie
- Luca Lipani
- Cristian Volpato
Absent
- Ismaël Koné (injury)
- Fedde Leysen (injury)
- Daniel Boloca (Knee injury.)
- Fali Candé (Cruciate ligament injury.)
Lazio
Starters
- 1 Christos Mandas
- 2 Romano Floriani Mussolini
- 3 Danilho Doekhi
- 4 Oliver Provstgaard
- 5 Nuno Tavares
- 6 Davide Frattesi
- 7 Reda Belahyane
- 8 Kenneth Taylor
- 9 Gustav Isaksen
- 10 Tijjani Noslin
- 11 Mattia Zaccagni
Bench
- Ivan Provedel
- Mario Gila
- Nicolò Casale
- Elseid Hysaj
- Manuel Lazzari
- Danilo Cataldi
- Daichi Kamada
- Matteo Guendouzi
- Matteo Cancellieri
- Pedro
- Ciro Immobile
Absent
- Alessio Furlanetto (injury)
- Albert Gudmundsson (injury)
- Nicolò Rovella (injury)
- Samuel Gigot (injury)
- Luca Pellegrini (Thigh injury.)
- Patric (Sprained Ankle.)
Low confidence
Both lineups carry a speculative tag, sourced from last known XIs adjusted for injuries, so the picture here may shift before kickoff. That said, a 4-3-3 versus 4-3-3 contest is anticipated, setting up a mirror-image tactical battle across the Mapei Stadium pitch.
Domenico Berardi offers Sassuolo a focal point in the final third, while Lazio's wide threat through Mattia Zaccagni and Gustav Isaksen could stretch the home side's defensive shape. The midfield collision between Nemanja Matić and Davide Frattesi promises to be central to how this fixture unfolds.
Our Verdict
Lazio's flawless away record of three wins from three, combined with Sassuolo's inconsistent home form and the loss of Fedde Leysen to a long-term knee injury, makes the away win at 2.40 the standout selection. The visitors sit eight points clear of their hosts, boast a dominant head-to-head record with 14 victories in 24 meetings, and have conceded sparingly on the road. Danilo Cataldi's return strengthens Gattuso's midfield options further. Back Lazio to win, with over 2.5 goals at 1.75 offering additional value given both sides' attacking tendencies.
Frequently Asked Questions
What is the best bet for Sassuolo vs Lazio?
Lazio to win is the standout selection here. The visitors arrive unbeaten in all six Serie A fixtures, boasting a perfect away record, and sit five points clear of Sassuolo in the table. With Sassuolo's defence conceding at an alarming rate and the H2H heavily favouring Lazio, backing the away side at 2.40 represents genuine value.
What time does Sassuolo vs Lazio kick off?
Sassuolo vs Lazio kicks off at 17:30 UTC on Tuesday, 27th October 2026. The match takes place at the MAPEI Stadium, Città del Tricolore, Sassuolo's well-appointed home ground in Reggio Emilia, which regularly hosts top-flight Serie A football.
Where can I watch Sassuolo vs Lazio on TV?
Broadcast arrangements for Serie A fixtures vary by territory. We recommend checking your local listings, as rights holders differ across regions. In the United Kingdom, Serie A matches are typically available via Sky Sports or TNT Sports; however, always confirm with your provider ahead of kickoff to avoid disappointment.
What is Sassuolo's recent record against Lazio?
The head-to-head record makes for sobering reading for Sassuolo supporters. Across 24 meetings, Lazio have claimed 14 victories, and their most recent encounter, in March 2026, ended in a 2-1 win for the Roman side. Sassuolo have struggled consistently against this opposition, and recent history offers little encouragement for the home faithful.