Spurs take on the Saints at Wembley on Wednesday night, with both sides failing to win at the weekend.
Here is everything you need to know about the clash.
Having being impressively beaten Chelsea the week before, Spurs slipped out of the top four following their 4-2 defeat in the North London derby at the weekend.
However, they did look impressive at times during the game against Arsenal, and you would expect them to get back to winning ways.
Southampton, also known as managerless Southampton, come into this having actually earned a valiant draw against Manchester United at the weekend.
However, with a rough run of fixtures ahead of them, they remain in the bottom three after surrendering a two-goal lead, leaving Mark Hughes to become the second managerial casualty of the season.
Tottenham: Lloris, Aurier, Foyth, Alderweireld, Rose, Winks, Dier, Son, Eriksen, Moura, Kane.
Southampton: McCarthy, Stephens, Yoshida, Vestergaard, Valery, Hojbjerg, Ward-Prowse, Soares, Armstrong, Redmond, Gabbiadini
Who is the referee?
Is Spurs v Southampton on TV?
Not in the UK, but it is available on NBC Sports Gold for our readers in the USA.
What time is kick off?
Spurs – 9/25
Draw – 17/4
Southampton – 17/2